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2024年4月4日 2 pyy发挥代谢调节效能的潜在作用机制 pyy作为一种介导饱腹感的激素,在机体摄入足够的食物后从远端肠道的内分泌l细胞分泌,在pyy136被dpp4分解为pyy336后通过肠神经刺激中枢神经使大脑与胃肠道相互作用,与弓状核中的y2受体结合抑制食欲,表现出
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Although the role of peptide YY (PYY) as a regulator of energy homeostasis was first highlighted only in 2002, our understanding of the physiological role of PYY has since rapidly advanced In recent years, insights from mechanistic studies in patients undergoing bariatric surgery, from pancreatic islet research, from functional neuroimaging studies, and from
2016年5月3日 PYY infusion in diabetic rats lowers body weight and HbA1c levels (Pittner et al, 2004), but its impact on impaired islet function remains unknown We tested the effects of PYY directly on islets isolated from severely diabetic GK rats (plasma glucose: 26
2009年1月1日 Circulating PYY PYY is released from the gut into the circulation in a nutrientdependent manner PYY levels are low in the fasting state, rapidly increase in response to food intake, reach a peak at 1–2 h after a meal and then remain elevated for several hours (Adrian et al 1985)In response to food intake PYY levels increase within
2012年6月26日 Since PYY is postprandially released from intestinal L cells, the peptide is thought to be a satiety signal, which fits with its effect to reduce food intake (McGowan and Bloom, 2004) Once released, PYY is in part cleaved to PYY 3–36 which, unlike the parent peptide, is a preferential agonist at Y2 receptors (Small and Bloom, 2005; Cox, 2007b)
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2018年1月8日 PeptideYY (PYY) and GlucagonLike Peptide1 (GLP1) play important roles in the regulation of food intake and insulin secretion, and are of translational interest in the field of obesity and
2021年10月8日 肽 yy(pyy)由位于空肠、回肠和结肠的l细胞产生,食物摄取(主要是脂肪)能刺激 pyy 的分泌。在消化道、胰腺和中枢神经系统中至少有五种不同的 gpcr 家族的y受体亚型(y1、y2、y4、y5、y6)均为肽 yy 受体。
2020年1月22日 PYY Plays a Key Role in the Improvement in Islet Function After Bariatric Surgery The levels of several gut hormones increase after either sleeve gastrectomy or gastric bypass as consequence of structural and functional changes in the gastrointestinal tract, including accelerated food delivery and absorption 16 Among these, over the past
2012年7月23日 PYY also elicited cholesterogenesis by translational regulation of HMGCoAR Small negative effects of PYY were noted on CM and LDL along with alterations of certain types of apo Finally, PYY was able to regulate specific transcription factors implicated in the regulation of lipid and cholesterol metabolism
2023年11月1日 Peptide YY (PYY) is a gastrointestinal hormone consisting of 36 amino acids, that is predominantly secreted by intestinal lcells Originally extracte
2013年6月10日 Functional changes in neuropeptide Y (NPY) signaling at the Y2 receptor subtype have been widely implicated in stressrelated neuropsychiatric illnesses such as depression and anxiety disorders
2022年12月29日 Among these is peptide YY (PYY), a 36 amino acid peptide, which is synthesized in the L cells (intestinal endocrine cells) of the distal part of the ileum, colon and rectum Its release occurs
2019年2月14日 The clinical utility of the gut hormone PYY to reduce food intake has been limited by vomiting Rangwala et al develop a new PYY analog that is well tolerated in obese rhesus macaques, without causing emesis The longacting PYY analog can be safely combined with liraglutide for further weight reduction
2009年1月1日 Several lines of evidence suggest that low circulating PYY concentrations predispose towards the development and or maintenance of obesity Subjects with reduced postprandial PYY release exhibit lower satiety and circulating PYY levels that correlate negatively with markers of adiposity In addition, mice lacking PYY are hyperphagic and
PP家族包括肽YY(peptide YY, PYY)和神经肽Y(neuropeptide Y, NPY),后两者均是根据化学结构发现的(具有羧基末端酪氨酸酰胺)。PP、PYY和NPY长度都是36个氨基酸,虽然结构相似,但却在消化道和神经系统的不同部位被发现,且生物功能不同。
PYY may contribute to the modulation of the secretion of GHR in normal weight, premenopausal women Plasma PYY levels increase both in obese adolescents and in obese adults, irrespective of eating rate; slow feeding behavior is more effective in stimulating PYY release/secretion in obese adolescents than in obese adults
2022年11月25日 PYY is mainly produced by endocrine Lcells of the distal ileum and colon (Fig 1) and is released postprandially in response to food ingestionUpon release into the bloodstream, PYY (1–36) is rapidly degraded by the ubiquitous enzyme dipeptidyl peptidase4 (DPP4), which removes the Nterminal dipeptide Tyr1Pro2, and generates the PYY
2009年10月9日 Rationale: Obesity is a heritable trait that contributes to hypertension and subsequent cardiorenal disease risk; thus, the investigation of genetic variation that predisposes individuals to obesity is an important goal Circulating peptide YY (PYY) is known for its appetite and energy expenditureregulating properties; linkage and
Summary Peptide YY (PYY) is a 36amino acid peptide hormone structurally related to two other gut peptide hormones, pancreatic polypeptide and neuropeptide Y Together, they are called the pancreatic polypeptidepeptide YYneuropeptide Y (PPPYYNPY) family of peptides or the PPfold family of peptides
pyy(pyyhuman)是一种被广泛研究药物靶点或生物标志物的化合物。pyy是一种糖蛋白,由两个多肽链组成,可以在多种组织和器官中表达。研究表明,pyy可以作为药物靶点,与多种药物发生相互作用,包括镇痛药、镇静药、降血压药和抗生素等。
2007年10月14日 Functional magnetic resonance imaging is used to examine brain areas whose activity correlates with subsequent feeding behaviour under different satiety states evoked by intravenous peptide YY3
2024年6月17日 PYY provided by HGNC Official Full Name peptide YY provided by HGNC Primary source HGNC:HGNC:9748 See related Ensembl:ENSG MIM:; AllianceGenome:HGNC:9748 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage
Peptid YY (PYY) ist ein Peptidhormon, welches aus 36 Aminosäuren besteht Es hat die Summenformel C 194 H 295 N 55 O 57Es wird beim Menschen in den endokrinen Zellen des distalen Dünndarms gefunden (vorwiegend im Ileum) und dort freigesetzt Die Freisetzung von PYY erfolgt hauptsächlich induziert durch FetteErstmals gefunden
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Neuropeptide Y and Bone Formation Dr Paul A Baldock, in Translational Endocrinology of Bone, 2013 Peptide YY Peptide YY is a member of the NPY family, released in response to feeding by L cells in the ileum and colon; however, low levels have been detected in the brain stem [6]Two forms of PYY exist in the circulation, the full length PYY136 and the
2022年2月14日 The human neuropeptide Y (NPY) acts through Gprotein coupled receptors and is involved in food intake, stress response, anxiety, and memory retention Here, the authors show that, unlike in other
Introduction Peptide YY (PYY), a gut peptide released after food intake (De Silva et al, 2011), increases during aerobic exercise (Broom et al, 2008)The relationship between exercise and plasma PYY depends on exercise type and form of PYY measured (ie, total PYY or PYY 336) (Hazell et al, 2016)Postexercise increases in PYY are posited to be
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2019年2月14日 The gut hormone PYY 3–36 reduces food intake in humans and exhibits at least additive efficacy in combination with GLP1 However, the utility of PYY analogs as antiobesity agents has been severely limited by emesis and rapid proteolysis, a profile similarly observed with native PYY 3–36 in obese rhesus macaques Here, we found that
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2023年3月3日 Además, los estudios en humanos han encontrado que las personas obesas tienen niveles más bajos de PYY en comparación con las personas con un peso saludable Sin embargo, es importante destacar que aunque los niveles bajos de PYY están asociados con la obesidad, esto no significa necesariamente que la falta de PYY cause
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The hormone PYY is released from the distal gut in response to nutrient ingestion Numerous studies have shown that PYY336, the most abundant circulating isoform of PYY, reduces food intake when given to obese rodents and humans Its infusion to mimic postprandial levels in fasting subjects inhibit
肽 YY: 该基因编码神经肽 Y (NPY) 肽家族的成员。编码的前原蛋白经过蛋白水解处理,生成两种长度相差三个氨基酸的替代肽产物。这些肽由肠道内分泌细胞分泌,对每种神经肽 Y 受体表现出不同的结合亲和力。编码的肽与这些受体的结合介导了胰腺分泌、肠道流动性和能量稳态的调节。该基因的